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Cyanocobalamin is popular and effective, but hydroxocobalamin might offer unique benefits
n = 643 placebo) confirmed that 40 mg/day consistently reduced OFF time (SMD = -0.28, 95% CI = -0.44 to -0.12, p = 0.0005), while the effect of 20 mg/day was less consistent (SMD = -0.23, 95% CI = -0.40 to -0.06, p = 0.009) and lost when certain studies were excluded
Furthermore, obese patients exhibited higher Humanin expression than those with type 2 diabetes, suggesting that obesity specifically upregulates Humanin in muscle
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