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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)

(2016) The glutathione derivative GSHmonoethyl ester may enhance pheomelanin formation, International Journal of Molecular Sciences, [online]

The mechanism likely involves correction of oxidative stress and modulation of glutamate signaling via the cystine-glutamate antiporter (system Xc-) [73][74]

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Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders