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Panel B shows the time course of functional hepatocytes after an 18 g dose of APAP

Even at doses far exceeding the standard 10 mcg/kg range (scaled to human-equivalent doses of roughly 200-800 mcg/day for a 70-kg adult), researchers have not observed pathological angiogenesis, tumorigenic signaling, or behavioral toxicity 1

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High-throughput screening in MADD cell lines has identified several lumichrome derivatives that restore mutant ETFDH activity at micromolar concentrations, validating the concept of pharmacological riboflavin agonists (76)