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The ability of mitochondria to rapidly adapt to stress, including stress imposed by antimetabolites such as 5FU, means that they have significant potential to dictate therapeutic responses 11

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doi: 10.3389/fphys.2025.1497566 Received 17 September 2024 Accepted 22 January 2025 Published 10 February 2025 Volume 16 - 2025 Edited by Hongxiang Hui, Monterey Park, United States Reviewed by Phiwayinkosi V

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No blend-level human data: there is no registered clinical trial of the KLOW blend, so its combined safety profile is not established in humans