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Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions

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Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, et al

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