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When the doughnut gets squished, the outer part bulges out, but the jelly stays inside

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STEVENSON, D.E

is a membranebound enzyme that preferentially catalyzes the methylation of aliphatic sulfhydryl compounds such as captopril and Dpenicillamine, whereas is a cytoplasmic enzyme that preferentially catalyzes the methylation of aromatic and heterocyclic sulfhydryl compounds including anticancer and immunosuppressive thiopurines such as 6mercaptopurine, 6thioguanine, and azathioprine