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The benefit profile is real, but the magnitude is typically modest compared to modern combination therapies
The sp 3 carbon scaffold of the pinane rings offered an effective way to capture interactions with the hydrophobic portions of subpocket C while also displacing likely trapped waters
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Zhao, L.-B
GLP-1 Agonists : Semaglutide (Wegovy) Tirzepatide (Zepbound) Liraglutide (Saxenda) 2
