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The authors also examined the synergistic effect of naringenin with sertraline in mice with depression and discovered that the combination of these two substances alleviated depressive-like behavior through the regulation of the 5-HT level and protection of the mitochondrial complexes pathway, as well as by reducing oxidative stress in the hippocampus
[DOI] [PMC free article] [PubMed] [Google Scholar] 123
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CBF reductions Individuals and animals with AD exhibit reductions in CBF and impaired cerebrovascular reactivity, particularly in the hippocampus, thalamus, frontal, and occipital cortices, as assessed by arterial spin labeling magnetic resonance imaging [157, 177, 178]
[11] [4] Preclinical studies have suggested that combining amylin receptor agonism with GLP-1based therapies produces greater reductions in food intake and body weight than either approach in isolation, and early clinical data from the CagriSema programme (cagrilintide combined with semaglutide) has provided some supporting evidence in humans
