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The JAK pathway inhibitor, tofacitinib, regulated the Treg/Th17 cell ratio in CIA mice and suppressed NLRP3 activation, whereas administration of NLRP3 abrogated this effect of tofacitinib, suggesting that NLRP3 played a pivotal role in the process of tofacitinib-mediated Th17 cell activation (144)

doi:10.1093/clinchem/30.6.884

In other embodiments, the otic formulations or compositions include a mucoadhesive excipient to allow adhesion to the external mucous membrane of the round window

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Other ingredients, like glutathione, may not be so familiar