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have shown that mechanical load in vivo promotes the production of O 2 in mitochondria of chondrocytes, and the expression of SOD1 and SOD2 in mitochondria decreases, while mitochondrial dysfunction induced by superoxide in mitochondria will further lead to cartilage degeneration (Scott et al., 2010)

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404 Ablation of astrocytes also caused secondary damage to neurones translated into impaired working memory and learning

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7D), suggesting the lack of noticeable toxic effects