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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Vukojevic J., Vrdoljak B., Malekinusic D., Siroglavic M., Milavic M., Kolenc D., Boban Blagaic A., Bateljam L., Drmic D., Seiwerth S., et al

[333] found in the brains of Fmr1 -knockout (KO) mice elevated levels of ROS, GSH, markers of protein oxidation and lipid peroxidation in whole brains, and increased production of NADPH oxidase in the prefrontal cortex, cerebellum, and hippocampus

Clinical signs of mechanism activation Neuroprotective mechanisms: Stabilized or slowed visual field loss (glaucoma), maintained ganglion cell layer thickness on OCT, preserved optic nerve appearance

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria