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doi: 10.3748/wjg.v19.i5.742 249 SchlkeS

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If particulates persist after 15 minutes total, the peptide may have aggregated during manufacturing or shipping, or the vial experienced temperature abuse

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On the other hand, iron-triggered lipid peroxidation activates matrix metalloproteinase-9 (MMP-9), which degrades key tight junction proteins such as ZO-1 and occludin, thereby disrupting endothelial barrier structure and increasing vascular permeability (Kim et al., 2022)