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The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure

Practices such as meditation, yoga, or regular exercise can reduce cortisol levels and promote antioxidant balance

The 1x CYP substrate cocktail contained phenacetin (10 M), bupropion (10 M), mephenytoin (50 M), diclofenac (10 M), bufuralol (10 M) and midazolam (5 M)

17 Similar findings have been reported in analyses of subjects who underwent metabolic surgery compared with those who did not