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The binding of urokinase plasminogen activator to its receptor is instrumental for the activation of plasminogen to plasmin an important blood protease implicated in blood clot resolution, which has also been shown to degrade extracellular matrix and has been linked to cancer progression

Funding This review was supported by Grants from the National Natural Science Foundation of China (82101342 to LQ), Science and Technology Innovation Program of Hunan Province (2021SK53501 to HZ), Horizontal research Project (02220141 to HZ), and Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University

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As postulated by Zechmann (2020) and Otulak-Kozie et al