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Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management

doi: 10.2527/jas.2010-3596 126 WellsJEBerryEDKalchayanandNRempelLAKimMOliverWT

4e, Supplementary Fig

This depletion occurs through several mechanisms: Direct oxidation of glutathione by UV-generated free radicals Increased consumption of glutathione in neutralizing UV-induced oxidative stress Impairment of glutathione synthesis pathways due to UV damage As glutathione levels decrease, the skin's natural defense mechanisms against UV-induced damage become significantly weakened

Puts et al., 2017), which hampers the development of treatments