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The nationwide fortification of grains with folic acid was estimated to prevent 1,000 cases of neural tube defects in the years after it was implemented, but a CDC study showed that there were still about 3,000 babies born with neural tube defects each year, even with the mandated fortification.[ref] ufficient choline, vitamin B12, vitamin B6, riboflavin, thiamine, zinc, and methionine (protein) also plays a role in reducing the risk of neural tube defects

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MSC-Exos, which are nano-sized extracellular vesicles (30150 nm) loaded with bioactive materials such as proteins, lipids, and nucleic acids, have demonstrated significant therapeutic potential in tissue repair and immunomodulation [7,8,9]

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