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372,373 The mTOR pathway plays a significant role in DPN development by affecting autophagy and apoptosis in Schwann cells, myelin formation, and lipid metabolism, thereby influencing myelin and axonal integrity

In patients, HBV circulates in blood as virion DNA and exists in hepatocytes both in nuclear DNA forms (episomal cccDNA, deproteinized double-stranded DNA including relaxed circular DNA and linear DNA and integrated linear DNA) and in cytoplasmic core DNA forms 21

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Active autoimmune disease or severe uncontrolled inflammation: Several peptides modulate immune signaling

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