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Without adequate vitamin C, collagen synthesis slows, existing collagen degrades faster, and the structural integrity of skin, blood vessels, joints, and connective tissue throughout the body deteriorates at an accelerated rate

Nonetheless, challenges such as undefined optimal dosing, delivery routes, treatment schedules, and long-term safety uncertainties must be resolved before clinical translation

10.1016/0928-4257(93)90038-u 114 SikiricP.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)

In conclusion, in active CD with higher intensification of OxS, the antioxidant defence system is diminished and returns to normal values in remission

"NIH Launches Large Clinical Trial on EDTA Chelation Therapy for Coronary Artery Disease"