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In addition, as an epigenetic modification, DNA methylation can be involved in disease progression and serve as a marker of environmental exposures, such as tobacco smoking, lipid peroxidation, and inflammation ( GSTA4 promoter, which contains antioxidant response elements, may act as an adaptive mechanism through which they are transcriptionally activated during exposure to lipid peroxidation of the vascular wall in IA patients ( GSTA4 methylation may serve as a biomarker of vascular impairment in patients with IA

Future research should prioritize mechanistic studies using knockout and CRISPR-based models to precisely define the cellular pathways through which GLP-1RAs exert their anti-inflammatory and metabolic effects in the lung

Cancer Epidemiol Biomarkers Prev

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Not intended for direct injection without an active drug