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Human clinical trials A pilot Phase I clinical trial conducted on three males by the College of Medicine , Pharmacology Department, University of Arizona in Tucson, Arizona published in 1996 reported that, "Melanotan II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous penile erections

This could be a strategy to avoid accumulation of neuroactive peptides in the brain [98]

Abnormalities of glucose metabolism implicated in vitiligo Various glucose pathways defects have been implicated in vitiligo

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This can help prevent many of the symptoms of the disease