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Long-term diabetes can lead to an increase in myocardial collagen fibers and the degree of collagen cross-linking, which will aggravate myocardial fibrosis, make the myocardium stiffer, and raise the likelihood of heart conditions like heart attack and high blood pressure (Lorenzi, 1992)

[15] A recent study on melasma patients noted significantly higher levels of glutathione-peroxidase enzyme in patients compared to controls, confirming the role of oxidative stress in melasma

doi: 10.1172/JCI131859 43 YangYIshak GabraMBHanseEALowmanXHTranTQLiHet al

The Grx1-roGFP2 fusion protein allowed dynamic live imaging of the glutathione redox potential ( E GSH ) in different cellular compartments with high sensitivity and temporal resolution

doi:10.1038/273120a0