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In addition, stable knockdown of TrxR1 resulted in a significant decrease in melanin levels and tyrosinase activity in melanocytes [76]

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References Averill-Bates DA

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Ann Oncol 29(1):44-70, 2018

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HIF-1 is pivotal in this regulation, promoting the glycolytic pathway by activating the transcription of genes encoding GLUTs and glycolytic enzymes

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Overall, the occluded structure illustrates how OCTN2 accommodates the opposing charged moieties of carnitine, as well as an apparent secondary role for ordered solvent within the substrate-binding site

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