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The safety profile was consistent with GLP-1 receptor agonists, primarily featuring transient, mild-to-moderate gastrointestinal adverse events (e.g., nausea, 55%), with low discontinuation rates (6-8.4%)

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Do not use around the eyes

Next, we treated AC16 cells with increasing doses of rosiglitazone (25, 50, and 100 M) and WY-14643 (25, 50, and 100 M) to identify the minimum dose of rosiglitazone that increases PPARGC1A expression (Supplemental Figure 3, AC) and the maximum dose of WY-14643 that does not (Supplemental Figure 3, DF)

Among them, aberrant methylation of related genes is an important element in the development and progression of CRC [11, 12]