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Otic agents and/or other pharmaceutical agents disclosed herein are optionally incorporated within controlled release particles, lipid complexes, liposomes, nanoparticles, microspheres, nanocapsules or other agents which enhance or facilitate the localized delivery of the otic agent

Interestingly, the oocyte maturation was blocked at a very specific development stage (metaphase I arrest) where a sensor for DNA damage (Spindle Assembly Check point/Dna Damage Response) assesses the DNA integrity and blocks the oocyte maturation through the activation of a protein (ATM kinase)

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Glutathione is a peptide composed of amino acids and plays a role in redox reactions in the living body

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