331 Regulatory mechanisms Forkhead box protein O1 (FOXO1) has been found to activate Notch signaling and regulate cellular differentiation in myoblasts by facilitating Notch binding to the Hes1 promoter and activating downstream target genes
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92,96,100,103 In addition, it is also efficacious in the treatment of solid tumors, such as breast cancer, 102,104 lung cancer, 97,103,105 glioma, 103,106 prostate cancer, 107 kidney cancer, 108 bladder cancer, 109 colon cancer, 110 and hepatocellular carcinoma