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Its targeted mechanism of action offers a novel and promising approach to medical interventions in these areas

2 Manuscript formatting 2.1 Regulation of bone homeostasis by osteoblasts, osteoclasts, and key influencing factors Bone homeostasis is regulated by the dynamic balance between bone-forming osteoblasts and bone-resorbing osteoclasts, and is influenced by various systemic and cellular factors ( Figure 1 )

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There is an immense effort to reveal the underlying causes of TDP-43 pathology and the downstream cellular events that are perturbed in diseased neurons

To improve the local resolution of CTR-RAMP extracellular domains (ECDs), focused refinements (masking around receptors or ECD domains) were performed