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Research Applications and Differences AOD-9604 Applications: Fat-specific lipolysis studies in adipocytes Energy balance and fatty acid mobilization research Obesity and metabolic disorder preclinical models Cytoprotective studies related to lipid metabolism HGH Fragment Applications: Studying systemic metabolic effects of partial GH sequences Investigating growth-related or anabolic signaling in various tissues Preclinical exploration of IGF-1-mediated pathways Endocrine function and metabolic regulation research The key distinction lies in target specificity: researchers design AOD-9604 to focus on fat metabolism, whereas HGH fragments have broader effects and can influence multiple tissues

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771