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Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

To generate the CRISPR/Cas9-engineered Gmmorf2a/b mutant, gRNAs were designed using the CRISPR-P website ( Two 20-bp DNA fragments coding for the gRNA were inserted into the pCas9-MDC-sgRNA plasmid

TLK286 L--Glutamyl-3-(bis[bis(2-chloroethyl)amino-phosphinyl]oxy)ethylsulfonyl-L-alanyl-2-phenyl-[2 R ]-glycine hydrochloride salt (TLK286) represents the most promising GST-prodrug candidate

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It is a component of the glutathione-ascorbate cycle, a system that reduces poisonous hydrogen peroxide