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155 Depletion of HIF-1 shows impaired GSIS, due to the decreased basal and glucose-stimulated ATP concentration 155,156 (Fig

In addition to the traditional perforingranzyme and FasFas ligand cell death induction pathways, interferon- secreted by CD8+ T cells activated in antiPD-L1 therapy can down-regulate System X c expression to reduce cystine uptake and induce ferroptosis (152)

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