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Our results indicate that absence of GliT may lead to accumulation of intracellular gliotoxin which is reduced, non-enzymatically, by GSH, analogous to the situation in animal cells as demonstrated by Bernardo et al

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However, GSH is found in intracellular organelles including endoplasmic reticulum (ER), nucleus, and mitochondria to control compartment-specific needs and functions ( Mitochondria in mammalian cells generate most of the cellular energy by means of the oxidative phosphorylation (OXPHOS) that is essential for myriad cellular functions