1a), characterised for their ability to coordinate up to three copper(II) ions that promote DNA damage
10.1016/j.jpba.2012.04.035 87 ZhangW.YinK.LiB.ChenL
7) Detoxifying exogenous chemicals enzymes and drug metabolism networks with glutathione pathways are activated upon CR, but could be involved in anti-cancer and pro-cancer outcomes via mutagenesis and DNA damage/repair mechanisms
Upon binding to cytoplasmic glucocorticoid receptors (GR), corticosteroids induce translocation of GR complexes into the nucleus, where they interact with glucocorticoid response elements (GREs) to upregulate anti-inflammatory genes (e.g., IL-10, DUSP-1) and suppress pro-inflammatory mediators like IL-1, IL-6, TNF-, and chemokines, such as MCP-1 and IL-8 (McManus 2003
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