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There are no known contraindications

Additionally, the highest levels of pro-BDNF are observed perinatally, then it declines with age, although the proform remains detectable in adulthood

In humans the effect is much less dramatic, and alcohol consumption causes a transient two-fold induction of CYP-2E1 ([43, 46])

A 2020 preclinical toxicity review found no serious toxicity in mice, rats, rabbits, or dogs at tested doses, but longterm human carcinogenicity or organtoxicity data are missing

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