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Experimental investigations from cellular cultures found the activation of NRF-2 by high doses of glucose, but there was variability between type of cellular pedigree and time of exposure [9193]

The potential role of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease

Selenium toxicity (selenosis) can occur with chronic excessive intake and may cause: Gastrointestinal disturbances (nausea, diarrhoea) Hair loss and brittle nails Skin rashes and lesions Neurological symptoms (peripheral neuropathy, fatigue, irritability) Garlic-like breath odour In severe cases, liver and kidney damage Safe consumption guidelines: Limit intake to one to two Brazil nuts per day to obtain selenium benefits whilst avoiding toxicity risk Avoid consuming Brazil nuts daily if taking selenium supplements Be aware that selenium content varies significantly between nuts Consider overall dietary selenium intake from other sources (fish, meat, eggs, cereals) Seek medical advice if you experience symptoms that might suggest selenosis Additional considerations: Brazil nuts are calorie-dense and may contribute to weight gain if consumed in large quantities

Reciprocal regulation of AMP-activated protein kinase and phospholipase D

athletes should maintain documentation and seek guidance before use