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These substances were initially identified for their profile in native (poly)phenols and then fermented with human fecal microbiota for 24 h

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To accomplish this, the trial was designed to focus on the assessment of objective endpoints such as small nerve fiber quantification by using both skin biopsy and corneal confocal microscopy and to relate these findings to semiobjective sensory testing by using QST, which directly assesses the effects of potential changes in cutaneous innervation