D is the 3.2 mg KLOW dose, M is the vials total 80 mg, and V_draw is the selected draw volume in mL: V water = V draw M D Worked example: 3.2 mg total KLOW in a 0.2 mL, or 20-unit, draw
Twice-weekly dosing protocols reduce total vial punctures by 60% versus daily administration, meaningfully lowering cumulative bacterial contamination probability
doi: 10.1080/0097840X.1975.9940405
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