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Dong J, Wang W, Zhou W, Zhang S, Li M, Li N

IB degradation exposes the nuclear localization signal on NF-B, thus allowing the nuclear translocation of the subunit and activation of the transcription of its target genes (Fig

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Furthermore, when we resolved the affinity purified P complexes assembled in the absence or presence of ICP27 by glycerol gradient sedimentation, we observed that the P complexes assembled in the presence of ICP27 failed to reach higher density fractions and spread out into more gradient fractions (Supplementary Fig