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Biomolecular impairment, increased toxicity, and the induction of apoptotic cell death are caused by the increased presence of carbonyl compounds, which are a result of reactive carbonylated species and their interactions with nucleophilic substrates (61)

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10.1038/ncb1123 [DOI] [PubMed] [Google Scholar] 29.Hosaka T, Biggs WH 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC