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An academic research project must clarify from the outset which framework it is destined for, which conditions the nature of data to generate (regulatory toxicology, controlled trials, pharmacovigilance)

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The pivotal SURMOUNT and SURPASS trial programs primarily focused on weight loss and glycemic outcomes, with reproductive health not designated as a primary endpoint

4.2 Consistent Label Construction for Pairwise DDOIs CAPSC provides an intermediate label construction strategy between relying on a single optimal dual solution and applying a conservative bound test over the entire optimal dual face

Neuroinflammation Neuronal loss in PD is associated with chronic neuroinflammation, which is controlled primarily by microglia, the major resident immune cells in the brain (Perry, 2012)