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93 Impaired SIRT1 function decreases PPAR activity, leading to lipid metabolism disorders, increased hepatic lipid deposition, and aggravated inflammatory responses

Studies conducted on an asymptomatic mouse model of HUA, subjected to acute kidney injury instigated by ischemia-reperfusion (IR-AKI), revealed that sUA could drive macrophage polarization toward the M2 macrophages, thereby expediting the recovery of renal function and structure in IR-AKI (75)

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