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Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy

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JAK2 activation in BPC-157-treated tendon fibroblasts occurs in a time-dependent manner following growth hormone stimulation, indicating the peptide primes cells for enhanced growth factor responsiveness rather than directly activating the pathway in the absence of the endogenous ligand

The promoting effect of pentadecapeptide BPC-157 on tendon healing involves tendon-outgrowth, cell survival and cell migration