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This hypothesis was supported in a recent study with a 20-year follow-up, which found chronic low dose exposure to POPs predicted excess adiposity, dyslipidemia, and insulin resistance among participants without diabetes, in a U-shaped fashion (characteristic of endocrine disruption)

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Figure 5 Mechanistic insights and knowledge gaps of ferroptosis in osteoporosis Significant progress has been made in understanding how ferroptosis affects osteogenic cells

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This cascading event is exacerbated by aging with a declining proteostasis, thereby reducing the cells ability to protect its more vulnerable proteins from coaggregation, eventually resulting in the collapse of essential cellular functions