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4.2 Mechanism of action of PDEVs 4.2.1 Intercellular communication and signal regulation PDEVs have emerged as a promising candidate for next-generation drug delivery systems, as they can encapsulate and deliver large quantities of bioactive molecules (Mu et al., 2014

Although mTORC1 activation hinders autophagy, evidence has shown that autophagy can be upregulated in tumors with mTORC1 hyperactivation 168

doi: 10.1146/annurev-pharmtox-010814-124742 78 ReppertSMWeaverDRGodsonC

For co-culture experiments, 510 MSC/mL were seeded per well and left to adhere for 24 hours (h)

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