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There is evidence that the level of adverse events is less than those reported for varenicline and the costs of cytisine do not appear to be prohibitive to the recommendation. In a phase III trial, 33% of participants using cytisinicline for 12 weeks abstained from smoking during weeks 9 to 12 of the trial, compared with 7% of people taking a placebo

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Those who started early had higher respiratory carbon monoxide levels compared with those who started late (19 vs

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