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Indeed, this magnitude appeared to increase with the Brnsted nuc values of the corresponding reactions of LMW thiolates with each electrophile, which in turn correlate with the amount of charge transferred in the transition state ( In the case of protein cysteines, the effect of persulfidation on the nucleophilic reactivity compared with the corresponding thiol is variable, and depends not only on the particular protein but also on the electrophile as well as on experimental conditions such as pH

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