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Loeb, L.A., 1994

While the HONC was developed for a dichotomous scoring system with any item endorsement indicating loss of autonomy over smoking [32], we measured it as a continuous marker of the degree of autonomy as has been done previously with non-daily smokers [16, 31]

22, 2013), 37 Fed

It achieves this by acting as a physical barrier preventing them from entering into the submucosa, by trapping them in mucous and expelling them through ciliary clearance, and by orchestrating their clearance by the immune system