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Konstantinos Farsalinos, concluded that a preliminary analysis does not support the argument that current smoking is a risk factor for hospitalization for COVID-19. It went on to speculate that nicotine may have beneficial effects on COVID-19, although it added that other confounding factors need to be considered and the accuracy of the recorded smoking status needs to be determined. Another study, led by French neuroscientist Jean-Pierre Changeux, similarly speculated that nicotine could prevent coronavirus

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found that overexpression of PGC-1 in muscle cells reduced oxidative stress and inflammation, suggesting that promoting mitochondrial biogenesis can have anti-inflammatory effects (St-Pierre et al., 2006)