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Please note that there is a great variation in the way that different commercial systems prepare and activate the PRP, and hence it is difficult to draw clear conclusions on the efficacy of PRP

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No human pharmacokinetic data has been published

The compound must survive the harsh environment of the stomach and be absorbed through the gut wall

Finally, it should be mentioned that RGD-containing scaffolds used to deliver growth factors, such as BMP-2 to promote bone regeneration in experimental fracture models, exist with favourable results [150]