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Other factors that can lead to smokers lines are: Genetics Repeated facial expressions, like pouting and smiling Drinking from a straw/bottle Dental problems Playing musical instruments, like the harmonica and flute Chronic dryness of the lips and skin around the mouth Best treatments for smokers lines The best treatment for smokers lines depends on your lip and skin condition and your desired results

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Level of recommendation: strong.18,19,37 Studies with varenicline show data up to 12 months of follow-up