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The probe plate was then inserted into the Seahorse XF analyser and, after 15 min of calibration, the cell plate was inserted into the analyser

Cycle Length: 4 weeks of daily dosing, followed by 24 weeks off to evaluate progress and allow receptor resetting

In case of low bile acid absorption, FXR is not activated, FGF19 stays low and bile acid synthesis is stimulated

Funding Dr Gurpreet Kaur Grewal acknowledges Department of Science & Technology, India for the SERB TARE grant (TAR/2022/000636) from Anusandhan National Research Foundation (ANRF), Govt

Triple Agonists Adding glucagon agonism to GLP-1/GIP agonism creates triple agonists currently in clinical trials