is tobacco substance abuse Mythbusters: One addiction at a time? Addressing Tobacco - NYC TCTTAC

They discovered that guys who smoke a lot had 29% less sperm and their sperm didn't move as well as guys who didn't smoke

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Journal of Substance Abuse

Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: Correlation with in vivo reduced glutathione concentration and membrane protein oxidation